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- Title
Angiotensin converting enzyme inhibition, AT1 receptor inhibition, and combination therapy with pacing induced heart failure: effects on left ventricular performance and regional blood flow patterns.
- Authors
Krombach, R S; Clair, M J; Hendrick, J W; Houck, W V; Zellner, J L; Kribbs, S B; Whitebread, S; Mukherjee, R; de Gasparo, M; Spinale, F G
- Abstract
AT1 receptor activation has been demonstrated to cause increased vascular resistance properties which may be of particular importance in the setting of congestive heart failure (CHF). The overall goal of this study was to examine the effects of ACE inhibition (ACEI) alone, AT1 receptor blockade alone and combined ACEI and AT1 receptor blockade on LV pump function, systemic hemodynamics and regional blood flow patterns in the normal state and with the development of pacing induced CHF, both at rest and with treadmill induced exercise.
- Publication
Cardiovascular research, 1998, Vol 38, Issue 3, p631
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(98)00050-9