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- Title
Activation of Flk-1/KDR mediates angiogenesis but not hypotension.
- Authors
Malavaud, B; Tack, I; Jonca, F; Praddaude, F; Moro, F; Ader, J L; Plouët, J
- Abstract
The concept of therapeutic angiogenesis with vascular endothelial growth factor (VEGF) has been validated in peripheral arterial disease. Its use in myocardial ischemia may be delayed as the result of the description in a porcine model of peripheral vasodilation after intraluminal injections of VEGF resulting in a 50% fatality rate by hypotension. We carried out this study to test whether VEGF-induced hypotension (1) is species specific, (2) is mediated by the receptor mediating angiogenesis, (3) is prevented by inhibition of nitric oxide synthase.
- Publication
Cardiovascular research, 1997, Vol 36, Issue 2, p276
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(97)00177-6