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- Title
Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium.
- Authors
Kögler, Harald; Fraser, Heather; McCune, Sylvia; Altschuld, Ruth; Marbán, Eduardo
- Abstract
Xanthine oxidase (XO) inhibitors enhance myofilament Ca(2+) responsiveness of normal rat myocardium. We examined whether this inotropic action is preserved or magnified in failing rat myocardium and whether the magnitude of this effect correlates with tissue xanthine-oxidoreductase (XOR) activity.
- Publication
Cardiovascular research, 2003, Vol 59, Issue 3, p582
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(03)00512-1