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- Title
Molecular basis of endothelial dysfunction in sepsis.
- Authors
Peters, Kirsten; Unger, Ronald E; Brunner, Joachim; Kirkpatrick, C James
- Abstract
Sepsis is one of the major causes of mortality in critically ill patients and develops as a result of the host response to infection. A complex network of events is set into motion in the body by the infection and results in the pathogenesis of sepsis. This review article focuses on the molecular mechanisms and components involved in the pathogenesis of sepsis with a major emphasis on the endothelium. This includes sepsis-inducing bacterial components (e.g. endotoxins), cellular targets of these molecules and their responses, host reactions, intracellular and cytokine networks, individual susceptibility and new therapeutic targets in sepsis treatment.
- Publication
Cardiovascular research, 2003, Vol 60, Issue 1, p49
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(03)00397-3