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- Title
Microvascular permeability is related to circulating levels of tumour necrosis factor-alpha in pre-eclampsia.
- Authors
Anim-Nyame, Nick; Gamble, John; Sooranna, Suren R; Johnson, Mark R; Steer, Philip J
- Abstract
The mechanism for the increased microvascular permeability which, underline many of the complications of pre-eclampsia, remain unexplained. It has been suggested that a factor present in the maternal circulation in pregnancies complicated by the disease may be responsible for increased microvascular permeability. In this study, we have investigated the relationship between filtration capacity (K(f)), an index of microvascular permeability, and maternal levels of VEGF, leptin and TNF-alpha, all of which are known permeability factors whose plasma levels are increased in pre-eclampsia.
- Publication
Cardiovascular research, 2003, Vol 58, Issue 1, p162
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(02)00844-1