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- Title
Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo.
- Authors
Morishige, Kunio; Shimokawa, Hiroaki; Matsumoto, Yasuharu; Eto, Yasuhiro; Uwatoku, Toyokazu; Abe, Kohtaro; Sueishi, Katsuo; Takeshita, Akira
- Abstract
Matrix metalloproteinases (MMPs) cause extracellular matrix degradation and may be involved in the rupture of atherosclerotic plaques by degrading fibrous cap, resulting in the intravascular thrombus formation. Here we examined whether local overexpression of MMP-9 alters the characteristics of arteriosclerotic vascular lesions and promotes thrombosis after balloon injury in porcine coronary arteries in vivo.
- Publication
Cardiovascular research, 2003, Vol 57, Issue 2, p572
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(02)00710-1