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- Title
The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.
- Authors
Mbai, Mackenzi; Rajamani, Sridharan; January, Craig T
- Abstract
The antimalarial drug halofantrine has been associated with QT interval prolongation and with fatal and nonfatal arrhythmias in patients without known underlying cardiac abnormalities. A common target for QT interval-prolonging drugs is the human ether-a-go-go gene (HERG) which encodes the pore forming subunit of the rapidly activating delayed rectifier K(+) current (I(Kr)).
- Publication
Cardiovascular research, 2002, Vol 55, Issue 4, p799
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(02)00448-0