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- Title
Increased connexin43 gap junction protein in hamster cardiomyocytes during cold acclimatization and hibernation.
- Authors
Saitongdee, P; Milner, P; Becker, D L; Knight, G E; Burnstock, G
- Abstract
The physiology of hibernation is characterized by dramatic reductions of heart rate, respiration, metabolism, blood pressure and body temperature and by resistance to ventricular fibrillation. Gap junctions in the heart provide low resistance pathways, facilitating electrical and metabolic coupling between cardiac muscle cells for coordinated action of the heart and tissue homeostasis. The conductance of these junctions, and therefore their function, is likely to be affected by the physiological changes that take place during hibernation. Our objective was to quantitate gap junction protein levels in cold acclimatization, hibernation and arousal.
- Publication
Cardiovascular research, 2000, Vol 47, Issue 1, p108
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(00)00051-1