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- Title
The impact of donor natural killer cell alloreactivity on allogeneic hematopoietic transplantation.
- Authors
Ruggeri, Loredana; Capanni, Marusca; Mancusi, Antonella; Martelli, Massimo F; Velardi, Andrea
- Abstract
Although natural killer (NK) cells are triggered to kill by many activating receptors, lysis of autologous cells is blocked by inhibitory receptors (called Killer cell Ig-like receptors or KIRs) which recognize epitopes shared by certain major histocompatibility complex (MHC) class I allele groups (called KIR ligands). As these inhibitory receptors are clonally distributed, they constituted a repertoire containing different allospecificities. Thus, the NK cells in the repertoire are lytic against allogeneic targets that do not express their inhibitory KIR ligands. In hematopoietic human-leukocyte-antigen (HLA)-haplotype mismatched transplantation, donor-vs-recipient alloreactive NK cells improve engraftment, decrease the incidence of leukemia relapse and do not cause Graft-vs-Host disease (GvHD). Pre-transplant molecular high-resolution HLA of recipient and donor, KIR genotyping of the donor and direct assessment of the donor NK repertoire identify donors with the potential for donor-vs-recipient NK cell alloreactivity.
- Publication
Transplant immunology, 2005, Vol 14, Issue 3-4, p203
- ISSN
0966-3274
- Publication type
Journal Article
- DOI
10.1016/j.trim.2005.03.008