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- Title
Therapeutic cloning applications for organ transplantation.
- Authors
Koh, Chester J; Atala, Anthony
- Abstract
A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
- Publication
Transplant immunology, 2004, Vol 12, Issue 3-4, p193
- ISSN
0966-3274
- Publication type
Journal Article
- DOI
10.1016/j.trim.2003.12.006