We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antiproliferative effect of Canavalia brasiliensis lectin on B16F10 cells.
- Authors
Silva, Flávio de Oliveira; Santos, Priscila das Neves; Figueirôa, Evellyne de Oliveira; de Melo, Cristiane Moutinho Lagos; de Andrade Lemoine Neves, Juliana Kelle; Arruda, Francisco Vassiliepe Sousa; Cajazeiras, João Batista; do Nascimento, Kyria Santiago; Teixeira, Edson Holanda; Cavada, Benildo Sousa; Porto, Ana Lúcia Figueiredo; Pereira, Valéria Rêgo Alves
- Abstract
Lectins are proteins or glycoproteins with the ability to link to carbohydrates at the cell surface in a specific and reversible manner. Studies have showed that lectins are demonstrate immunomodulatory and antitumor agents. This study aims to evaluate the effect of lectin extracted from the seeds of Canavalia brasiliensis (ConBr) on murine melanoma B16F10 cells by analyzing cell viability, apoptosis index, cell migration, production of cytokines and nitric oxide (NO). Results showed that ConBr was able to reduce cell viability and thwart apoptosis, which could be observed by decrease in cell migration. ConBr also induced NO and IL-12 synthesis. Altogether, these data demonstrate the potential of ConBr as a therapeutic agent for melanoma.
- Publication
Research in veterinary science, 2014, Vol 96, Issue 2, p276
- ISSN
1532-2661
- Publication type
Journal Article
- DOI
10.1016/j.rvsc.2014.01.005