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- Title
Vitreous biomarkers in diabetic retinopathy: a systematic review and meta-analysis.
- Authors
McAuley, Annie K; Sanfilippo, Paul G; Hewitt, Alex W; Liang, Helena; Lamoureux, Ecosse; Wang, Jie Jin; Connell, Paul P
- Abstract
The aim of this study was to perform a systematic meta-analysis of biomarkers investigated with diabetic retinopathy (DR) in the vitreous, and to explore the molecular pathway interactions of these markers found to be consistently associated with DR. Relevant databases [PubMed and ISI web of science] were searched for all published articles investigating molecular biomarkers of the vitreous associated with DR. Based on set exclusion/inclusion criteria available data from studies with human vitreous samples were extracted and used for our meta-analysis. The interactions of significant biomarkers in DR were investigated via STRING and KEGG pathway analysis. Our meta-analysis of DR identifies eleven biomarkers as potential therapeutic candidates alternate to current anti-VEGF therapy. Four of these are deemed viable therapeutic targets for PDR; ET receptors (ET A and ET B), anti-PDGF-BB, blocking TGF-β using cell therapy and PEDF. The identification of supplementary or synergistic therapeutic candidates to anti VEGF in the treatment of DR may aid in the development of future treatment trials.
- Publication
Journal of diabetes and its complications, 2014, Vol 28, Issue 3, p419
- ISSN
1873-460X
- Publication type
Journal Article
- DOI
10.1016/j.jdiacomp.2013.09.010