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- Title
The compromised inflammatory response to bacterial components after pediatric cardiac surgery is associated with cardiopulmonary bypass-suppressed Toll-like receptor signal transduction pathways.
- Authors
Li, Yi-ping; Huang, Jie; Huang, Shun-gen; Xu, Yong-gen; Xu, Yun-yun; Liao, Jian-yi; Feng, Xing; Zhang, Xue-guang; Wang, Jiang Huai; Wang, Jian
- Abstract
Cardiopulmonary bypass (CPB) during pediatric cardiac surgery often elicits a systemic inflammatory response followed by a compromised immune response, which has been attributed to the morbidity of postoperative infection; however, the underlying mechanism(s) has not yet been fully elucidated. We hypothesized that CPB inhibits the activation of Toll-like receptor (TLR) signal transduction pathways, thereby causing an immunosuppressive state after pediatric cardiac surgery.
- Publication
Journal of critical care, 2014, Vol 29, Issue 2, p312.e7-13
- ISSN
1557-8615
- Publication type
Journal Article
- DOI
10.1016/j.jcrc.2013.10.008