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- Title
Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.
- Authors
Sampson, Laura J; Davies, Lowri M; Barrett-Jolley, Richard; Standen, Nick B; Dart, Caroline
- Abstract
The vasoconstrictor angiotensin II (Ang II) acts at G(q/11)-coupled receptors to suppress ATP-sensitive potassium (K(ATP)) channel activity via activation of protein kinase C (PKC). The aim of this study was to determine the PKC isoforms involved in the Ang II-induced inhibition of aortic K(ATP) channel activity and to investigate potential mechanisms by which these isoforms specifically target these ion channels.
- Publication
Cardiovascular research, 2007, Vol 76, Issue 1, p61
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/j.cardiores.2007.05.020