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- Title
Rescue of amitriptyline-intoxicated hearts with nanosized vesicles.
- Authors
Dhanikula, Anand Babu; Lamontagne, Daniel; Leroux, Jean-Christophe
- Abstract
Amitriptyline, one of the most prescribed antidepressants, is reported to claim a large number of human lives due to drug overdose related cardiac arrest. Although amitriptyline poisoning has long been recognized as a frequent and serious fatality in the medical field, few efforts have been made to devise methods for treating its toxicity. To address this issue, phospholipid-based nanosized vesicles (spherulites) were employed to reverse the cardiotoxicity induced by amitriptyline in an isolated heart perfusion model.
- Publication
Cardiovascular research, 2007, Vol 74, Issue 3, p480
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/j.cardiores.2007.02.017