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- Title
Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors.
- Authors
Müller, Oliver J; Leuchs, Barbara; Pleger, Sven T; Grimm, Dirk; Franz, Wolfgang-M; Katus, Hugo A; Kleinschmidt, Jürgen A
- Abstract
Vectors based on recombinant adeno-associated virus 2 (AAV-2) are a promising tool for cardiac gene transfer. However, potential therapeutic applications need to consider the predominant transduction of the liver once AAV-2 vectors enter the systemic circulation. We therefore aimed to increase efficiency and specificity of cardiac vector delivery by combining transcriptional and cell surface targeting.
- Publication
Cardiovascular research, 2006, Vol 70, Issue 1, p70
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/j.cardiores.2005.12.017