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- Title
Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.
- Authors
Narolska, N A; van Loon, R B; Boontje, N M; Zaremba, R; Penas, S Eiras; Russell, J; Spiegelenberg, S R; Huybregts, M A J M; Visser, F C; de Jong, J W; van der Velden, J; Stienen, G J M
- Abstract
Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow isoform is upregulated; however, the functional implications of this transition in human myocardium are largely unknown. The aim of this study was to determine the relation between contractile properties and MHC isoform composition in healthy human myocardium using the diversity in atrial tissue.
- Publication
Cardiovascular research, 2005, Vol 65, Issue 1, p221
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/j.cardiores.2004.09.029