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- Title
Variants in the 5'-upstream region of GPC5 confer risk of lung cancer in never smokers.
- Authors
Liu, Li; Zhong, Rong; Zou, Li; Fu, Jinjian; Zhu, Beibei; Chen, Wei; Ye, Xiaohua; Gao, Yanhui; Yang, Yi; Christiani, David C; Chen, Sidong; Miao, Xiaoping
- Abstract
A recent genome-wide study (GWAS) has identified GPC5 as a promising susceptibility gene for Lung cancer in never smokers (LCINS). However, the most significant single nucleotide polymorphism (SNP) in this GWAS, rs2352028, has yielded controversial results. The aim of this study was to clarify the relationship between rs2352028 and LCINS. Considering that rs2352028 might be largely marker-SNP correlated to causative variants, two predicted functional SNPs, rs3759452 and rs7322083, were additionally investigated in this study.
- Publication
Cancer epidemiology, 2014, Vol 38, Issue 1, p66
- ISSN
1877-783X
- Publication type
Journal Article
- DOI
10.1016/j.canep.2013.12.009