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Title
Indinavir concentrations and St John's wort.
Authors
Piscitelli, S C; Burstein, A H; Chaitt, D; Alfaro, R M; Falloon, J
Abstract
St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.