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Title
Hypocretin (orexin) deficiency in human narcolepsy.
Authors
Nishino, S; Ripley, B; Overeem, S; Lammers, G J; Mignot, E
Abstract
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.