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Title
Subtle chromosomal rearrangements in children with unexplained mental retardation.
Authors
Knight, S J; Regan, R; Nicod, A; Horsley, S W; Kearney, L; Homfray, T; Winter, R M; Bolton, P; Flint, J
Abstract
No explanation for moderate to severe mental retardation is apparent in about 40% of cases. Although small chromosomal rearrangements may account for some undiagnosed cases, a lack of genome-wide screening methods has made it impossible to ascertain the frequency of such abnormalities.