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- Title
Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study.
- Authors
Wilkinson, R J; Llewelyn, M; Toossi, Z; Patel, P; Pasvol, G; Lalvani, A; Wright, D; Latif, M; Davidson, R N
- Abstract
Susceptibility to disease after infection by Mycobacterium tuberculosis is influenced by environmental and host genetic factors. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of M. tuberculosis. This effect may be influenced by polymorphisms at three sites in the vitamin D receptor (VDR) gene. We investigated the interaction between serum vitamin D (25-hydroxycholecalciferol) concentrations and VDR genotype on susceptibility to tuberculosis.
- Publication
Lancet (London, England), 2000, Vol 355, Issue 9204, p618
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(99)02301-6