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- Title
Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints.
- Authors
Levi, M; Cromheecke, M E; de Jonge, E; Prins, M H; de Mol, B J; Briët, E; Büller, H R
- Abstract
Excessive bleeding may complicate cardiac surgery, and is associated with increased morbidity and mortality. Pharmacological strategies to decrease perioperative bleeding have been investigated in a large number of controlled trials, most of which have shown a decrease in blood loss. However, most studies lacked sufficient power to detect a beneficial effect on clinically more relevant outcomes. We did a meta-analysis of all randomised, controlled trials of the three most frequently used pharmacological strategies to decrease perioperative blood loss (aprotinin, lysine analogues [aminocaproic acid and tranexamic acid], and desmopressin).
- Publication
Lancet (London, England), 1999, Vol 354, Issue 9194, p1940
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(99)01264-7