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Title
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.
Authors
Stankovic, T; Weber, P; Stewart, G; Bedenham, T; Murray, J; Byrd, P J; Moss, P A; Taylor, A M
Abstract
Patients with the inherited disorder ataxia telangiectasia (A-T) have an increased susceptibility to lymphoid malignancies. In these patients mutations affect both alleles of the A-T gene (ATM). We have looked for mutations in the ATM gene in sporadic cases of B-cell chronic lymphocytic leukaemia (B-CLL).