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- Title
Effect of antenatal betamethasone administration on placental vascular resistance.
- Authors
Wallace, E M; Baker, L S
- Abstract
High placental vascular resistance is an important cause of fetal growth restriction and subsequent perinatal mortality. Identification of affected pregnancies allows appropriate fetal surveillance and delivery, but there are no known therapeutic strategies to decrease resistance and improve blood flow. However, placental corticotropin-releasing hormone (CRH) is thought to be a potent fetoplacental vasodilator, and exogenous corticosteroids can increase placental CRH secretion. Therefore, we examined whether corticosteroids could improve fetoplacental blood flow in pregnancies with increased vascular resistance.
- Publication
Lancet (London, England), 1999, Vol 353, Issue 9162, p1404
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(98)08229-4