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- Title
Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training.
- Authors
Montgomery, H; Clarkson, P; Barnard, M; Bell, J; Brynes, A; Dollery, C; Hajnal, J; Hemingway, H; Mercer, D; Jarman, P; Marshall, R; Prasad, K; Rayson, M; Saeed, N; Talmud, P; Thomas, L; Jubb, M; World, M; Humphries, S
- Abstract
The function of local renin-angiotensin systems in skeletal muscle and adipose tissue remains largely unknown. A polymorphism of the human angiotensin converting enzyme (ACE) gene has been identified in which the insertion (I) rather than deletion (D) allele is associated with lower ACE activity in body tissues and increased response to some aspects of physical training. We studied the association between the ACE gene insertion or deletion polymorphism and changes in body composition related to an intensive exercise programme, to investigate the metabolic effects of local human renin-angiotensin systems.
- Publication
Lancet (London, England), 1999, Vol 353, Issue 9152, p541
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(98)07131-1