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- Title
Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). Ramipril Efficacy in Nephropathy.
- Authors
Ruggenenti, P; Perna, A; Gherardi, G; Gaspari, F; Benini, R; Remuzzi, G
- Abstract
The Ramipril Efficacy In Nephropathy (REIN) study found that in patients with chronic nephropathies and proteinuria of 3 g or more per 24 h, ramipril safely reduced the rate of decline of the glomerular filtration rate (GFR) and halved the combined risk of doubling of serum creatinine or end-stage renal failure (ESRF), as compared with placebo plus conventional antihypertensive drugs at the same level of blood pressure control. At the end of the core study patients continued on or shifted to ramipril and were formally enrolled into the REIN follow-up study.
- Publication
Lancet (London, England), 1998, Vol 352, Issue 9136, p1252
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(98)04433-x