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- Title
Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection.
- Authors
Gough, A; Clapperton, M; Rolando, N; Foster, A V; Philpott-Howard, J; Edmonds, M E
- Abstract
Diabetic foot infections cause substantial morbidity and mortality. Neutrophil superoxide generation, a crucial part of neutrophil bactericidal activity, is impaired in diabetes. Granulocyte-colony stimulating factor (G-CSF) increases the release of neutrophils from the bone marrow and improves neutrophil function. We assessed G-CSF as adjuvant therapy for the treatment of severe foot infections in diabetic patients.
- Publication
Lancet (London, England), 1997, Vol 350, Issue 9081, p855
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(97)04495-4