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- Title
Conformational disease.
- Authors
Carrell, R W; Lomas, D A
- Abstract
Several diverse disorders, including the prevalent dementias and encephalopathies, are now believed to arise from the same general disease mechanism. In each, there is abnormal unfolding and then aggregation of an underlying protein. The gradual accumulation of these aggregates and the acceleration of their formation by stress explain the characteristic late or episodic onset of the clinical disease. The understanding of these processes at the molecular level is opening prospects of more rational approaches to investigation and therapy.
- Publication
Lancet (London, England), 1997, Vol 350, Issue 9071, p134
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(97)02073-4