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- Title
Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile?
- Authors
Rook, G A; Zumla, A
- Abstract
The symptoms of Gulf War syndrome are compatible with the hypothesis that the immune system of affected individuals is biased towards a Th2-cytokine pattern. Factors that could lead to a Th2 shift among Gulf War veterans include exposure to multiple Th2-inducing vaccinations under stressful circumstances and the way in which such vaccinations were administered, which would be expected to maximise Th2 immunogenicity. These factors may have led to a long-term systemic shift towards a Th2-cytokine balance and to mood changes related to the immunoendocrine state. Other vaccines that lead to similar long-term, non-specific shifts in cytokine balance are well-established. If our hypothesis is proven, treatment may be possible with regimens that induce a systemic Th1 bias.
- Publication
Lancet (London, England), 1997, Vol 349, Issue 9068, p1831
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(97)01164-1