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- Title
Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium.
- Authors
Pellegrini, G; Traverso, C E; Franzi, A T; Zingirian, M; Cancedda, R; De Luca, M
- Abstract
Complete loss of the corneal-limbal epithelium leads to re-epithelialisation by bulbar conjunctival cells. Since conjunctival and corneal-limbal epithelial cells represent two different cell lines, this conjunctival healing of the cornea is followed by stromal scarring, decreased visual acuity, and severe discomfort. Unilateral corneal-limbal epithelial defects can be resolved by the transplantation of limbal grafts taken from the uninjured eye. However, this procedure requires a large limbal graft to be taken from the healthy eye, and is not possible for bilateral lesions. We investigated the possibility of restoring the human corneal surface with autologous corneal epithelial sheets generated by serial cultivation of limbal cells.
- Publication
Lancet (London, England), 1997, Vol 349, Issue 9057, p990
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(96)11188-0