We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Herpes simplex virus type 1 in brain and risk of Alzheimer's disease.
- Authors
Itzhaki, R F; Lin, W R; Shang, D; Wilcock, G K; Faragher, B; Jamieson, G A
- Abstract
The apolipoprotein E epsilon 4 (APOE-epsilon 4) allele is a risk factor for Alzheimer's disease (AD), but it is neither essential nor sufficient for development of the disease. Other factors-genetic or environmental-must therefore have a role. By means of a PCR we have detected herpes simplex virus type 1 (HSV1) in latent form in brains of elderly people with and without AD. We have postulated that limited reactivation of the virus causes more damage in AD patients than in elderly people without AD because of a difference in the hosts. We now report the APOE genotypes of AD patients and non-AD sufferers with and without HSV1 in brain.
- Publication
Lancet (London, England), 1997, Vol 349, Issue 9047, p241
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(96)10149-5