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- Title
Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease.
- Authors
Iyo, M; Namba, H; Fukushi, K; Shinotoh, H; Nagatsuka, S; Suhara, T; Sudo, Y; Suzuki, K; Irie, T
- Abstract
Acetylcholinesterase activity, a marker for degeneration of the central cholinergic system, has consistently been reported, in necropsy brain studies, to be reduced in the cerebral cortex of patients with Alzheimer's disease. We have shown regional acetylcholinesterase activity in vivo in rodent and primate brains with radioactive acetylcholine analogues. In the present study, we used one of the analogues to map acetylcholinesterase activity in the brains of living people.
- Publication
Lancet (London, England), 1997, Vol 349, Issue 9068, p1805
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(96)09124-6