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- Title
Diastolic ventricular interaction in chronic heart failure.
- Authors
Atherton, J J; Moore, T D; Lele, S S; Thomson, H L; Galbraith, A J; Belenkie, I; Tyberg, J V; Frenneaux, M P
- Abstract
Diastolic ventricular interaction describes a situation in which the volume of one ventricle is directly influenced by the volume of the other ventricle. Such interaction is normally negligible, but it is accentuated in circumstances associated with pulmonary hypertension and volume overload. When this interaction occurs, acute volume unloading results in a reduction in right ventricular end-diastolic volume, as expected, but left ventricular end-diastolic volume paradoxically increases. Since chronic heart failure is a volume-overloaded state associated with pulmonary hypertension, we hypothesised that this interaction may be clinically important in patients with heart failure.
- Publication
Lancet (London, England), 1997, Vol 349, Issue 9067, p1720
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(96)05109-4