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- Title
Interleukin-10 production during septicaemia.
- Authors
Marchant, A; Devière, J; Byl, B; De Groote, D; Vincent, J L; Goldman, M
- Abstract
Interleukin-10 is produced during incubation of human whole blood with bacterial lipopolysaccharide (LPS) and down-regulates tumour necrosis factor-alpha production in this in-vitro model of endotoxaemia. 39 out of 69 (57%) patients with gram-negative (n = 25) or gram-positive septicaemia (n = 44) had increased plasma interleukin-10 (range 12-2740 pg/mL), whereas interleukin-10 was undetectable in 29 out of 33 control patients without infection and in 20 healthy volunteers. Patients with septic shock (n = 21) had higher interleukin-10 (main 58 pg/mL) than septicaemic patients without shock (11 pg/mL, p < 0.001). We conclude that interleukin-10 is produced during sepsis and might be involved in the control of the inflammatory response induced by bacterial products.
- Publication
Lancet (London, England), 1994, Vol 343, Issue 8899, p707
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(94)91584-9