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- Title
Botulinum toxin for chronic anal fissure.
- Authors
Gui, D; Cassetta, E; Anastasio, G; Bentivoglio, A R; Maria, G; Albanese, A
- Abstract
Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.
- Publication
Lancet (London, England), 1994, Vol 344, Issue 8930, p1127
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(94)90633-5