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- Title
Dietary polyunsaturated fatty acids and composition of human aortic plaques.
- Authors
Felton, C V; Crook, D; Davies, M J; Oliver, M F
- Abstract
How long-term dietary intake of essential fatty acids affects the fatty-acid content of aortic plaques is not clear. We compared the fatty-acid composition of aortic plaques with that of post-mortem serum and adipose tissue, in which essential fatty-acid content reflects dietary intake. Positive associations were found between serum and plaque omega 6 (r = 0.75) and omega 3 (r = 0.93) polyunsaturated fatty acids, and monounsaturates (r = 0.70), and also between adipose tissue and plaque omega 6 polyunsaturated fatty acids (r = 0.89). No associations were found with saturated fatty acids. These findings imply a direct influence of dietary polyunsaturated fatty acids on aortic plaque formation and suggest that current trends favouring increased intake of polyunsaturated fatty acids should be reconsidered.
- Publication
Lancet (London, England), 1994, Vol 344, Issue 8931, p1195
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(94)90511-8