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- Title
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
- Authors
Baxter, E Joanna; Scott, Linda M; Campbell, Peter J; East, Clare; Fourouclas, Nasios; Swanton, Soheila; Vassiliou, George S; Bench, Anthony J; Boyd, Elaine M; Curtin, Natasha; Scott, Mike A; Erber, Wendy N; Green, Anthony R; Cancer Genome Project
- Abstract
Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which are polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. The molecular pathogenesis of these disorders is unknown, but tyrosine kinases have been implicated in several related disorders. We investigated the role of the cytoplasmic tyrosine kinase JAK2 in patients with a myeloproliferative disorder.
- Publication
Lancet (London, England), 2005, Vol 365, Issue 9464, p1054
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(05)71142-9