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- Title
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.
- Authors
Le Blanc, Katarina; Rasmusson, Ida; Sundberg, Berit; Götherström, Cecilia; Hassan, Moustapha; Uzunel, Mehmet; Ringdén, Olle
- Abstract
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
- Publication
Lancet (London, England), 2004, Vol 363, Issue 9419, p1439
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(04)16104-7