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- Title
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
- Authors
Smith, Gillian; Wolf, C Roland; Deeni, Yusuf Y; Dawe, Robert S; Evans, Alan T; Comrie, Muriel M; Ferguson, James; Ibbotson, Sally H
- Abstract
Treatment of common skin diseases such as psoriasis is complicated by differences between individuals in response to topical drug treatment and photochemotherapy. Individuality in hepatic expression of drug-metabolising enzymes is an important determinant of systemic drug handling; we investigated whether similar variation in cutaneous gene expression contributes to individuality in response to topical therapies.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9366, p1336
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)13081-4