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- Title
Genetic associations in large versus small studies: an empirical assessment.
- Authors
Ioannidis, John P A; Trikalinos, Thomas A; Ntzani, Evangelia E; Contopoulos-Ioannidis, Despina G
- Abstract
Advances in human genetics could help us to assess prognosis on an individual basis and to optimise the management of complex diseases. However, different studies on the same genetic association sometimes have discrepant results. Our aim was to assess how often large studies arrive at different conclusions than smaller studies, and whether this situation arises more frequently when findings of first published studies disagree with those of subsequent research.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9357, p567
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)12516-0