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- Title
Viability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy.
- Authors
Hagège, Albert A; Carrion, Claire; Menasché, Philippe; Vilquin, Jean-Thomas; Duboc, Denis; Marolleau, Jean-Pierre; Desnos, Michel; Bruneval, Patrick
- Abstract
Autologous skeletal myoblast transplantation might improve postinfarction ventricular function, but graft viability and differentiation (ie, proof of concept) has not been shown. A 72-year-old man had autologous cultured myoblasts from his vastus lateralis injected to an area of transmural inferior myocardial infarction in non-reperfused scar tissue. He showed improvement in symptoms and left-ventricular ejection fraction. When he died 17.5 months after the procedure, the grafted post-infarction scar showed well developed skeletal myotubes with a preserved contractile apparatus. 65% of myotubes expressed the slow myosin isoform and 33% coexpressed the slow and fast isoforms (vs 44% and 0.6%, respectively, in skeletal muscle). Myoblast grafts can survive and show a switch to slow-twitch fibres, which might allow sustained improvement in cardiac function.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9356, p491
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)12458-0