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- Title
Association between conformational mutations in neuroserpin and onset and severity of dementia.
- Authors
Davis, Richard L; Shrimpton, Antony E; Carrell, Robin W; Lomas, David A; Gerhard, Lieselotte; Baumann, Bruno; Lawrence, Daniel A; Yepes, Manuel; Kim, Tai Seung; Ghetti, Bernardino; Piccardo, Pedro; Takao, Masaki; Lacbawan, Felicitas; Muenke, Maximilian; Sifers, Richard N; Bradshaw, Charles B; Kent, Paul F; Collins, George H; Larocca, Daria; Holohan, Peter D
- Abstract
The aggregation of specific proteins is a common feature of the familial dementias, but whether the formation of neuronal inclusion bodies is a causative or incidental factor in the disease is not known. To clarify this issue, we investigated five families with typical neuroserpin inclusion bodies but with various neurological manifestations.
- Publication
Lancet (London, England), 2002, Vol 359, Issue 9325, p2242
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(02)09293-0