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- Title
Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study.
- Authors
Vadhan-Raj, Saroj; Kavanagh, John J; Freedman, Ralph S; Folloder, Jody; Currie, Laura M; Bueso-Ramos, Carlos; Verschraegen, Claire F; Narvios, Aida B; Connor, Jerome; Hoots, William K; Broemeling, Lyle D; Lichtiger, Benjamin
- Abstract
The increasing demand for platelet products, and concern over the transfusion-associated risks of alloimmunisation and infections, have motivated a search for improved methods aimed at keeping exposure to donor antigens to a minimum. Transfusion of thrombopoietin-derived autologous platelets might provide an alternative strategy. We aimed to compare the safety and efficacy of this strategy with that of transfusion with fresh allogeneic platelets in patients with severe chemotherapy-induced thrombocytopenia.
- Publication
Lancet (London, England), 2002, Vol 359, Issue 9324, p2145
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(02)09090-6