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- Title
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.
- Authors
Mallal, S; Nolan, D; Witt, C; Masel, G; Martin, A M; Moore, C; Sayer, D; Castley, A; Mamotte, C; Maxwell, D; James, I; Christiansen, F T
- Abstract
The use of abacavir--a potent HIV-1 nucleoside-analogue reverse-transcriptase inhibitor--is complicated by a potentially life-threatening hypersensitivity syndrome in about 5% of cases. Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir.
- Publication
Lancet (London, England), 2002, Vol 359, Issue 9308, p727
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(02)07873-x