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- Title
Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial.
- Authors
Raz, I; Elias, D; Avron, A; Tamir, M; Metzger, M; Cohen, I R
- Abstract
Type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic beta cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self antigens. An immunomodulatory peptide from hsp60, p277, arrested beta-cell destruction and maintained insulin production in newly diabetic NOD mice. We did a randomised, double-blind, phase II study of peptide treatment in patients with newly diagnosed (<6 months) type 1 diabetes.
- Publication
Lancet (London, England), 2001, Vol 358, Issue 9295, p1749
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(01)06801-5