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- Title
In-vivo measurement of activated microglia in dementia.
- Authors
Cagnin, A; Brooks, D J; Kennedy, A M; Gunn, R N; Myers, R; Turkheimer, F E; Jones, T; Banati, R B
- Abstract
Activated microglia have a key role in the brain's immune response to neuronal degeneration. The transition of microglia from the normal resting state to the activated state is associated with an increased expression of receptors known as peripheral benzodiazepine binding sites, which are abundant on cells of mononuclear phagocyte lineage. We used brain imaging to study expression of these sites in healthy individuals and patients with Alzheimer's disease.
- Publication
Lancet (London, England), 2001, Vol 358, Issue 9280, p461
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(01)05625-2