We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey.
- Authors
Roushdy-Hammady, I; Siegel, J; Emri, S; Testa, J R; Carbone, M
- Abstract
Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.
- Publication
Lancet (London, England), 2001, Vol 357, Issue 9254, p444
- ISSN
0140-6736
- Publication type
Research
- DOI
10.1016/S0140-6736(00)04013-7