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- Title
Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood.
- Authors
Holloway, J A; Warner, J O; Vance, G H; Diaper, N D; Warner, J A; Jones, C A
- Abstract
Mononuclear cells in umbilical-cord blood display allergen-specific reactivity, but how allergen exposure occurs in utero is unknown. We investigated the presence of a common inhalant allergen (Der p 1), to which mothers are exposed throughout pregnancy, by ELISA in matched maternal blood and amniotic fluid samples at 16-17 weeks of gestation, and in matched maternal and umbilical-cord blood at term (> or =37 weeks of gestation). Der p 1 was detectable in 24 of 43 amniotic fluid samples where it was also present in maternal blood, and in 15 of 24 cord-plasma samples at significantly higher concentrations than in the maternal plasma (p=0.022). The detection of Der p 1 in the amniotic fluid and the fetal circulation provides direct evidence of transamniotic and transplacental allergen exposure.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9245, p1900
- ISSN
0140-6736
- Publication type
Research
- DOI
10.1016/S0140-6736(00)03265-7