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- Title
Crohn's disease associated with spondyloarthropathy: effect of TNF-alpha blockade with infliximab on articular symptoms.
- Authors
Van den Bosch, F; Kruithof, E; De Vos, M; De Keyser, F; Mielants, H
- Abstract
Four patients with Crohn's disease and spondyloarthropathy were treated with infliximab for treatment-resistant gut inflammation. A substantial improvement in gastrointestinal signs and symptoms was noted, which was accompanied by a rapid reduction in C-reactive protein concentrations. Moreover, all four patients had a significant improvement of axial manifestations and/or peripheral arthritis, related to their spondyloarthropathy. This fast and substantial improvement of the articular manifestations of Crohn's disease after infliximab treatment warrants further investigation of the therapeutic potential of TNF-alpha blockade in other subtypes of spondyloarthropathies.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9244, p1821
- ISSN
0140-6736
- Publication type
Research
- DOI
10.1016/s0140-6736(00)03239-6